blisters

Don't puncture a blister unless it's painful or prevents you from walking or using one of your hands. If you have diabetes or poor circulation, call your doctor before considering the self-care measures below.
to relieve blister-related pain, drain the fluid while leaving the overlying skin intact. Here's how:

Wash your hands and the blister with soap and warm water.
Swab the blister with iodine or rubbing alcohol.
Sterilize a clean, sharp needle by wiping it with rubbing alcohol.
Use the needle to puncture the blister. Aim for several spots near the blister's edge. Let the fluid drain, but leave the overlying skin in place.
Apply an antibiotic ointment to the blister and cover with a bandage or gauze pad.
Cut away all the dead skin after several days, using tweezers and scissors sterilized with rubbing alcohol. Apply more ointment and a bandage.

A blister is a small pocket of fluid within the upper layers of the skin, typically caused by forceful rubbing (friction), burning, freezing, chemical exposure or infection. Most blisters are filled with a clear fluid called serum or plasma(aka, "blister water"). However, blisters can be filled with blood (known as blood blisters) or with pus (if they become infected).
Causes

Friction or rubbing-Intense rubbing can cause a blister, as can any friction on the skin if continued long enough. This kind of blister is most common after walking long distances or wearing a poorly-tuned new pair of shoes
Extreme temperature-The time of blistering is one of the tools used to determine the degree of burns sustained. First and second degree burns may result in blistered skin.
Chemical exposure-Sometimes, the skin will blister when it comes into contact with a cosmetic, detergent, solvent or other chemical. This is known as contact dermatitis. Blisters can also develop as a result of an allergic reaction to an insect bite or sting.
Crushing/Pinching-A blood blister usually forms when a minute blood vessel close to the surface of the skin ruptures (breaks) and blood leaks into a tear between the layers of skin. This can happen if the skin is crushed, pinched or aggressively squeezed